BackgroundThe protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
DescriptionPhospho-Jak3-Y980/981 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDP52333
PurificationAffinity Purification
ImmunogenA synthetic phosphorylated peptide around Y980 of human Jak3 (NP_000206.2).
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesJAK3; JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK; Janus kinase 3
ApplicationWB; Recommended dilution: WB: 1:500-1:2000