BackgroundThe protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
DescriptionJAK3 Recombinant Monoclonal Antibody [1C7]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP52333
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human JAK3
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesTyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK), JAK3
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200
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