Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion.
FARP2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Liquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, PH 7.4.
Protein G purified
Recombinant Human FERM, ARHGEF and pleckstrin domain-containing protein 2 protein (261-550AA)
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
FERM, RhoGEF and pleckstrin domain-containing protein 2, FARP2, KIAA0793, PLEKHC3, FERM domain including RhoGEF, FIR, Pleckstrin homology domain-containing family C member 3, PH domain-containing family C member 3
ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200