BackgroundPlays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
DescriptionCLN5 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, pH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDO75503
Purification>95%, Protein G purified
ImmunogenRecombinant Human Ceroid-lipofuscinosis neuronal protein 5 protein (42-181AA)
StorageShipped at 4°C. Upon receipt, store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesCeroid-lipofuscinosis neuronal protein 5, Protein CLN5, Ceroid-lipofuscinosis neuronal protein 5, secreted form, CLN5
ApplicationELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200