BackgroundMay have a role in regulating extra-urea cycle arginine metabolism and suppressing nitric oxide synthesis. Controls L-arginine availability to nitric oxide synthase (NOS), impacting immune responses. Potentially dampens activated CD4(+) and CD8(+) T cell survival, suppresses airway inflammation signals in asthma, and hinders M1 macrophage activation and polyamine metabolism in H.pylori immune evasion. In fetal dendritic cells, it may encourage immune suppression and T cell TNF-alpha production during gestation. Regulates RPS6KB1 signaling, promoting endothelial cell inflammation and dysfunction in NOS3/eNOS. Can inhibit endothelial autophagy through mTORC2 signaling. Also influences vascular smooth muscle cell senescence and apoptosis. In the context of sexual arousal, relevant to both male and female physiology given its presence in genital tissues.
DescriptionARG2 Recombinant Monoclonal Antibody [9A4]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP78540
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human ARG2
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesArginase-2, mitochondrial (EC 3.5.3.1) (Arginase II) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase), ARG2
ApplicationELISA, IHC, IF, FC; Recommended dilution: IHC:1:50-1:200, IF:1:50-1:200, FC:1:50-1:200