BackgroundArginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
DescriptionARG1 Recombinant Monoclonal Antibody [31D12]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP05089
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from Human ARG1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesArginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase), ARG1
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200