BackgroundBinds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
DescriptionANGPT2 Recombinant Monoclonal Antibody [1F10]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDO15123
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from human Angiopoietin 2
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesAngiopoietin-2 (ANG-2), ANGPT2
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200