BackgroundBinds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.
DescriptionANGPT2 Recombinant Monoclonal Antibody [5A9]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypehIgG1
Uniprot IDO15123
PurificationAffinity-chromatography
ImmunogenRecombinant Human ANGPT2 protein
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesAngiopoietin-2 (ANG-2), ANGPT2
ApplicationELISA