BackgroundSerine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.
DescriptionTMPRSS6 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ8IU80
Purification>95%, Protein G purified
ImmunogenRecombinant Human Transmembrane protease serine 6 protein (98-301AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesTransmembrane protease serine 6 (EC:3.4.21.-), TMPRSS6, UNQ354/PRO618, Matriptase-2
ApplicationELISA, IHC; Recommended dilution: IHC:1:20-1:200