STAT1 Recombinant Monoclonal Antibody [6C10]

Background
The protein produced by this gene belongs to the STAT protein family. When exposed to cytokines and growth factors, STAT family members experience phosphorylation through kinases connected to receptors. This phosphorylation prompts the formation of homo- or heterodimers, which move into the cell nucleus and act as activators of transcription. The protein resulting from this gene can be activated by diverse ligands, including interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. This protein facilitates the expression of various genes, believed to be crucial for cell survival in response to different cellular cues and pathogens. It assumes a significant role in immune responses against viral, fungal, and mycobacterial pathogens. Genetic mutations in this gene are linked to Immunodeficiency 31B, 31A, and 31C.

Description
STAT1 Recombinant Monoclonal Antibody [6C10]. Unconjugated. Raised in: HEK293F Cell.

Formulation
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human

Isotype
Rabbit IgG

Uniprot ID
P42224

Purification
Affinity Chromatography

Immunogen
A synthesized peptide derived from Human STAT1

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84), STAT1

Application
ELISA, IHC, IF, FC; Recommended dilution: IHC:1:50-1:200, IF:1:50-1:200, FC:1:50-1:200