BackgroundSulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.
Descriptionply Polyclonal Antibody, FITC Conjugated. FITC. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityStreptococcus pneumoniae serotype 4
IsotypeIgG
Uniprot IDP0C2J9
Purification>95%, Protein G purified
ImmunogenRecombinant Streptococcus pneumoniae serotype 4 Pneumolysin protein (2-471AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesThiol-activated cytolysin, SP_1923, ply
ApplicationELISA; Recommended dilution: ELISA 1:100-1:500