BackgroundFunctions as a tumor suppressor, inducing growth arrest or apoptosis based on cell type and context. Regulates cell cycle genes to control division. Triggers apoptosis via BAX/FAS or Bcl-2 pathways. Collaborates with PPIF for oxidative stress-induced necrosis. Drives lincRNA-p21 and lincRNA-Mkln1 transcription. Impacts Notch signaling, halts CDK7 during DNA damage, and modulates circadian clock. Isoforms have distinct effects on transcription, apoptosis, and growth.
DescriptionPhospho-TP53 (S33) Recombinant Monoclonal Antibody [3E7]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP04637
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-TP53 (S33)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesCellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53
ApplicationELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:20-1:200