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Phospho Histone H2A.X (Tyr142) Polyclonal Antibody

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Western blot analysis of extracts from Hela cells at a 1:2000 dilution using the Phospho Histone H2A.X (Tyr142) Polyclonal Antibody.
Application: WB
Areas of Research: Histone Phosphorylation & Dephosphorylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
100% Guarantee: 6 months
Catalog No.SizePriceQty
A68363-05050 µg $199.00 
A68363-100100 µg $299.00 
Availability: Usually Ships Within 1-2 Weeks 
Product Overview

Background
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Description
Phospho Histone H2A.X (Tyr142) Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH 7.4.

Specificity
Human, Mouse, Rat

Isotype
IgG

Uniprot ID
P16104

Immunogen
Synthetic Peptide

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
H2AFX; H2AX; Histone H2A.x; H2a/x

Application
WB: 1:1000-2000

VCU0006

User Guide & MSDS

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