BackgroundMetalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
DescriptionPAPPA Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ13219
Purification>95%, Protein G purified
ImmunogenRecombinant Human Pappalysin-1 protein (95-302AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesInsulin-like growth factor-dependent IGF-binding protein 4 protease, Pregnancy-associated plasma protein A, PAPPA
ApplicationELISA, IHC; Recommended dilution: IHC:1:20-1:200