BackgroundMultifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
DescriptionPACS2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, pH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ86VP3
Purification>95%, Protein G purified
ImmunogenRecombinant Human Phosphofurin acidic cluster sorting protein 2 protein (268-465AA)
StorageShipped at 4°C. Upon receipt, store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesPhosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein, PACS2, KIAA0602, PACS1L
ApplicationELISA, IHC; Recommended dilution: IHC: 1:200-1:500