BackgroundPlays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity). Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
DescriptionKRT10 Recombinant Monoclonal Antibody [18B6]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP13645
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from Human KRT10
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesKeratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10), KRT10, KPP
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200
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