BackgroundReceptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory.
DescriptionGRPR Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, pH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDP30550
Purification>95%, Protein G purified
ImmunogenRecombinant Human Gastrin-releasing peptide receptor protein (326-384AA)
StorageShipped at 4°C. Upon receipt, store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesGastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR
ApplicationELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200