BackgroundInvolved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
DescriptionGCSAM Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ8N6F7
Purification>95%, Protein G purified
ImmunogenRecombinant Human Germinal center-associated signaling and motility protein (1-178AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesGerminal center-associated signaling and motility protein, GCSAM, GAL, GCET2, Germinal center B-cell-expressed transcript 2 protein, Germinal center-associated lymphoma protein, hGAL
ApplicationELISA, IHC; Recommended dilution: IHC:1:20-1:200