 |
DNA Damage & Repair Antibodies
Cells undergo DNA damage constantly from exogenous and endogenous sources. Some of these sources include UV-light, ionizing radiation, alkylating agents and other environmental DNA damaging agents, as well as other sources derived spontaneously from cellular metabolism, such as reactive oxygen species. DNA damaging agents can cause a number of DNA lesions, including adducts, apurinic/apyrimidinic sites (AP sites), single-strand and double-strand DNA breaks. Left unrepaired, these DNA lesions could result in mutations, senescence, or induction of cell death which could lead to the development of neurodegeneration, cancer and other diseases.
In order to maintain genomic integrity, cells have developed the DNA damage response (DDR) pathway which allows cells to recognize the DNA damage and facilitate recruitment and activation of DNA repair proteins. Members of the phosphatidyl-inositol 3-kinase like protein kinase (PIKK) family, such as ATM, ATR and DNA-PK, are involved in this response, as well as a few members of the poly (ADP-ribose) polymerase (PARP) family.
Several DNA repair pathways exist to correct the DNA lesions depending on the particular form of DNA damage. For instance, the base excision repair (BER) and the mismatch repair (MMR) pathways mend damaged or mispaired DNA bases by excising the damaged base or by replacing mispaired bases with correct ones. Nucleotide excision repair (NER) fixes DNA lesions such as intrastrand crosslinks by removing a larger oligonucleotide DNA fragment; while double-strand breaks are generally repaired by non-homology end-joining (NHEJ) or by homology-directed repair (HDR). |
|
 |
|
|
|
| Result Pages: 8 |
Displaying 141 to 160 (of 169 products) |
STRA13 Polyclonal Antibody
| Application: |
ELISA, IHC |
| Areas of Research: |
Cell Cycle, DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A63516-020 | 20 µg | $99.00 |  |
| A63516-050 | 50 µg | $256.00 | |
| A63516-100 | 100 µg | $359.00 | |
STRA13 Polyclonal Antibody, Biotin Conjugated
| Application: |
ELISA |
| Areas of Research: |
Cell Cycle, DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
Biotin |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A63519-050 | 50 µg | $256.00 | |
| A63519-100 | 100 µg | $359.00 | |
STRA13 Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
Cell Cycle, DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A63518-050 | 50 µg | $256.00 | |
| A63518-100 | 100 µg | $359.00 | |
STRA13 Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
Cell Cycle, DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A63517-050 | 50 µg | $256.00 | |
| A63517-100 | 100 µg | $359.00 | |
TDG Polyclonal Antibody
| Application: |
WB |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Reactivity: |
Mouse, Rat |
| A-6704-050 | 50 µl | $273.00 | |
| A-6704-100 | 100 µl | $465.00 | |
TIPRL Polyclonal Antibody
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A61322-020 | 20 µg | $99.00 | |
| A61322-050 | 50 µg | $256.00 | |
| A61322-100 | 100 µg | $359.00 | |
| A61323-050 | 50 µg | $256.00 | |
| A61323-100 | 100 µg | $359.00 | |
TIPRL Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A61324-050 | 50 µg | $256.00 | |
| A61324-100 | 100 µg | $359.00 | |
TIPRL Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A61325-050 | 50 µg | $256.00 | |
| A61325-100 | 100 µg | $359.00 | |
XPC Polyclonal Antibody
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A53796-020 | 20 µg | $99.00 | |
| A53796-050 | 50 µg | $256.00 | |
| A53796-100 | 100 µg | $359.00 | |
XPC Polyclonal Antibody, Biotin Conjugated
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
Biotin |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A53793-050 | 50 µg | $256.00 | |
| A53793-100 | 100 µg | $359.00 | |
XPC Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A53794-050 | 50 µg | $256.00 | |
| A53794-100 | 100 µg | $359.00 | |
XPC Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A53795-050 | 50 µg | $256.00 | |
| A53795-100 | 100 µg | $359.00 | |
XRCC3 Polyclonal Antibody
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A57289-020 | 20 µg | $99.00 | |
| A57289-050 | 50 µg | $256.00 | |
| A57289-100 | 100 µg | $359.00 | |
| A57292-050 | 50 µg | $256.00 | |
| A57292-100 | 100 µg | $359.00 | |
XRCC3 Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A57291-050 | 50 µg | $256.00 | |
| A57291-100 | 100 µg | $359.00 | |
XRCC3 Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A57290-050 | 50 µg | $256.00 | |
| A57290-100 | 100 µg | $359.00 | |
XRCC5 Polyclonal Antibody
| Application: |
ELISA, IHC, WB |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A61806-020 | 20 µg | $99.00 | |
| A61806-050 | 50 µg | $256.00 | |
| A61806-100 | 100 µg | $359.00 | |
| A61807-050 | 50 µg | $256.00 | |
| A61807-100 | 100 µg | $359.00 | |
XRCC5 Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
DNA Damage & Repair |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A61808-050 | 50 µg | $256.00 | |
| A61808-100 | 100 µg | $359.00 | |
| Result Pages: 8 |
Displaying 141 to 160 (of 169 products) |
|
|
Home » Antibodies » Primary Antibodies » Cell Structure & Function Antibodies » DNA Damage & Repair Antibodies 
