COPS7B Polyclonal Antibody, HRP Conjugated

Background
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Description
COPS7B Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
Q9H9Q2

Purification
>95%, Protein G purified

Immunogen
Recombinant Human COP9 signalosome complex subunit 7b protein (1-157AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
COP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b, COPS7B, CSN7B

Application
ELISA; Recommended dilution: ELISA 1:500-1:1000