BackgroundCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).
DescriptionCDH2 Recombinant Monoclonal Antibody [1A9]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP19022
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human N Cadherin
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesCadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325), CDH2, CDHN NCAD
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200