BackgroundCD177 is a gene that encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that participates in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Myeloproliferative diseases is associated with mutations in this gene, and over-expression of this gene has been linked to polycythemia rubra vera disease. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene has been identified that neighbors this gene on chromosome 19.
DescriptionCD177 Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ8N6Q3
Purification>95%, Protein G purified
ImmunogenRecombinant Human CD177 antigen protein (22-321AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesCD177 antigen, Human neutrophil alloantigen 2a, HNA-2a, NB1 glycoprotein, NB1 GP, Polycythemia rubra vera protein 1, PRV-1, CD177, CD177, NB1, PRV1, UNQ595/PRO1181
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000