BackgroundBotulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-/-Phe-77' bond of synaptobrevin-2.
DescriptionbotB Polyclonal Antibody, FITC Conjugated. FITC. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityClostridium botulinum
IsotypeIgG
Uniprot IDP10844
Purification>95%, Protein G purified
ImmunogenRecombinant Clostridium botulinum Botulinum neurotoxin type B protein (1-427AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesBoNT/B, Bontoxilysin-B, botB
ApplicationELISA; Recommended dilution: ELISA 1:100-1:500