B4GAT1 Polyclonal Antibody, FITC Conjugated

Background
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE, during synthesis of phosphorylated O-mannosyl glycan (PubMed:25279699, PubMed:25279697). Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:25279697). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1).

Description
B4GAT1 Polyclonal Antibody, FITC Conjugated. FITC. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
O43505

Purification
>95%, Protein G purified

Immunogen
Recombinant Human Beta-1,4-glucuronyltransferase 1 protein (161-415AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Beta-1, 4-glucuronyltransferase 1, I-beta-1, 3-N-acetylglucosaminyltransferase, N-acetyllactosaminide beta-1, 3-N-acetylglucosaminyltransferase, Poly-N-acetyllactosamine extension enzyme, UDP-GlcNAc:betaGal beta-1, 3-N-acetylglucosaminyltransferase 1, B4GAT1, B3GNT1

Application
ELISA