BackgroundForms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity).
DescriptionAQP4 Recombinant Monoclonal Antibody [22F10]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP55087
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from Human AQP4
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesAquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4), AQP4
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200