BackgroundDioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
DescriptionALKBH3 Polyclonal Antibody, FITC Conjugated. FITC. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ96Q83
Purification>95%, Protein G purified
ImmunogenRecombinant Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 protein (1-170AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesAlkylated DNA repair protein alkB homolog 3, DEPC-1, Prostate cancer antigen 1, ABH3, DEPC1, ALKBH3
ApplicationELISA; Recommended dilution: ELISA 1:100-1:500
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