BackgroundCleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
DescriptionADAMTS4 Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDO75173
PurificationProtein G purified
ImmunogenRecombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 protein (213-319AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesADAM-TS 4, ADAM-TS4, ADAMTS-4, ADMP-1, Aggrecanase-1, ADAMTS4
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000
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