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AATF Polyclonal Antibody

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Western blot
All lanes: AATF Polyclonal Antibody at 2ug/ml
Lane 1: 293T whole cell lysate
Lane 2: EC109 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 62kDa
Observed band size: 50kDa
Application: ELISA, IHC
Areas of Research: Apoptosis & Cell Death, Cell Cycle, Transcription Factors
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
100% Guarantee: 6 months
Catalog No.SizePriceQty
A51673-02020 µg $59.00 
A51673-05050 µg $256.00 
A51673-100100 µg $359.00 
Availability: Usually Ships Within 1-2 Weeks 
Product Overview

Background
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Description
AATF Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
Q9NY61

Purification
>95%, Protein G purified

Immunogen
Recombinant Human Protein AATF protein (6-294AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Application
ELISA, IHC; Recommended dilution: IHC:1:50-1:200

User Guide & MSDS

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