BackgroundTK1 (Thymidine Kinase 1) is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates deoxythymidine monophosphate (dTMP) and is the first step in the biosynthesis of deoxythymidine triphosphate ( dTTP), which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers.
DescriptionTK1 Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDP04183
Purification>95%, Protein G purified
ImmunogenRecombinant Human Thymidine kinase, cytosolic protein (2-234AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesThymidine kinase, cytosolic , TK1
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000