BackgroundThe protein from this gene belongs to the STAT protein family. Following cytokine and growth factor stimulation, STAT family members are phosphorylated by associated kinases, forming homo- or heterodimers that enter the cell nucleus to act as transcription activators. This protein is activated via phosphorylation in response to various cytokines and growth factors, including IFNs, EGF, IL5, IL6, HGF, LIF, and BMP2. It orchestrates gene expression in response to cellular cues, playing a pivotal role in processes like cell growth and apoptosis. The small GTPase Rac1 regulates its activity by binding. PIAS3 protein specifically inhibits it. Additionally, this gene participates in regulating the host's response to viral and bacterial infections. Mutations in this gene correlate with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome.
DescriptionSTAT3 Recombinant Monoclonal Antibody [28H4]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypehIgG1
Uniprot IDP40763
PurificationAffinity Chromatography
ImmunogenRecombinant Human STAT3 protein
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesSignal transducer and activator of transcription 3 (Acute-phase response factor), STAT3, APRF
ApplicationELISA