BackgroundReceptor tyrosine-protein kinase with diverse roles: cell proliferation, migration, differentiation, and neuronal functions. Binds glial cell derived neurotrophic factor family ligands. Involved in intestinal, renal, and neural development. Influences cell adhesion, apoptosis, and survival balance. Acts as a dependence receptor, promoting survival with ligand and apoptosis without. Implicated in neuroendocrine cancers and neural crest development.
DescriptionRET Recombinant Monoclonal Antibody [8D12]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP07949
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Ret
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesProto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment, Extracellular cell-membrane anchored RET cadherin 120 kDa fragment], RET, CDHF12 CDHR16 PTC RET51
ApplicationELISA, FC; Recommended dilution: FC:1:20-1:200
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