Background TMPRSS2 plays an important role in the infection mechanism of human coronaviruses, such as SARS-CoV and SARS-CoV-2. Cell entry of human coronaviruses depends on the binding of the viral spike (S) glycoprotein to cellular ACE2 receptor and S protein priming by host cell protease TMPRSS2. This protein is commonly used to study cancer. Previous studies have shown that the encoding gene for TMPRSS2 protein was up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue.
Description The recombinant Transmembrane protease serine 2 (TMPRSS2); expressed in E.coli at the 106-492aa region of TMPRSS2.
Purity Greater than 90% as determined by SDS-PAGE.
Formulation Lyophilized powder; Buffer Tris-based buffer, 50% glycerol
Species Human
Calculated MW 46.9 kDa
Expressed Host E.coli (Expression Region 106-492aa)
Tag N-terminal 6xHis-tagged Uniprot ID O15393
Storage Store at -20°C upon receipt, aliquoting is necessary for multiple use. Avoid repeated freeze-thaw cycles. Alternative Names D16Ertd61e; Epitheliasin; FLJ41954; MGC6821; PP9284; PRSS10; Serine protease 10; TMPRSS2; TMPRSS2 ERG FUSION GENE, INCLUDED; TMPRSS2 ETV1 FUSION GENE, INCLUDED; TMPS2_HUMAN; Transmembrane protease serine 2 catalytic chain; Transmembrane protease, serine 2; Transmembrane protease, serine 2, EC 3.4.219