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N6-methyladenosine (m6A) Polyclonal Antibody


For antibody-based applications requiring high specificity to N6-methyladenosine (m6A)

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The N6-methyladenosine (m6A) Polyclonal Antibody tested in dot blot against total RNA of Arabidopsis
ELISA performed at 1:1000 dilution using N6-methyladenosine (m6A) Polyclonal Antibody.
The N6-methyladenosine (m6A) Polyclonal Antibody tested in nucleotide array against N6-methyladenosine (m6A) and unmodified adenosine (100pmol for each oligomer).
Oligomer 1 - N6-methyladenosine (m6A-CUGGUAACGAAUGGCU-G-Biotin)
Oligomer 2 - unmodified adenosine (ACUGGUAACGAAUGGCU-G-Biotin)
Oligomer 3 - unmodified adenosine (AAAAAAAAAAAAAAAAA-Biotin)
Application: DB, ELISA, ICC, IP, NucleotideArray
Areas of Research: RNA Methylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Broad Range, Human, Mouse
100% Guarantee: 6 months
Catalog No.SizePriceQty
A-1801-02020 µl $99.00 
A-1801-100100 µl $339.00 $271.20 
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Product Overview

N6-methyladenosine (m6A) is the most common and abundant modification in RNA molecules present in eukaryotes. The m6A modification is catalyzed by a methyltransferase complex METTL3 and removed by the recently discovered m6A RNA demethylases FTO and ALKBH5, which catalyze m6A demethylation in an α-ketoglutarate (α-KG)- and Fe2+-dependent manner. It was shown that METTL3, FTO, and ALKBH5 play essential roles in many biological processes, ranging from development and metabolism to fertility. m6A accounts for more than 80% of all RNA base methylations and exists in various species. m6A is mainly distributed in mRNA and also occurs in non-coding RNA such as tRNA, rRNA, and snRNA. The relative abundance of m6A in mRNA transcripts has been shown to affect RNA metabolism processes such as splicing, nuclear export, translation ability and stability, and RNA transcription. Abnormal m6A methylation levels induced by defects in m6A RNA methylase and demethylase could lead to dysfunction of RNA and diseases. For example, abnormally low levels of m6A in target mRNAs due to increased FTO activity in patients with FTO mutations, through an as-yet-undefined pathway, contributes to the onset of obesity and related diseases. The dynamic and reversible chemical m6A modification in RNA may also serve as a novel epigenetic marker of profound biological significance. Therefore, more useful information for a better understanding of m6A RNA methylation levels and distribution on RNA transcripts could benefit diagnostics and therapeutics of disease.

N6-methyladenosine (m6A) Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Liquid. PBS, PH 7.4.

Mouse, Human, Broad Range


Affinity purified

KLH-conjugated N6-methyladenosine (m6A)

Shipped at 4°C. Upon delivery aliquot and store at 4°C (short-term), or store at  20°C or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Anti-N6-methyladenosine, N6-methyladenosine, N6(methylnitroso)adenosine, m6A, N6-methyladenosine, 6mA

ELISA, DB, ICC, IP, Nucleotide Array; Recommended dilution: ELISA 1:1000, ICC: 1:50 - 1:100, IP: 1:50 - 1:100


User Guide & MSDS

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