MRAP2 Polyclonal Antibody, HRP Conjugated

Background
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.

Description
MRAP2 Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
Q96G30

Purification
>95%, Protein G purified

Immunogen
Recombinant Human Melanocortin-2 receptor accessory protein 2 protein (66-205AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117

Application
ELISA; Recommended dilution: ELISA 1:500-1:1000