BackgroundPromotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
DescriptionMAPT Recombinant Monoclonal Antibody [8C2]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityMouse, Macaca mulatta
IsotypehIgG4 (S228P)
Uniprot IDP10636
PurificationAffinity Chromatography
ImmunogenRecombinant Human MAPT protein
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesMicrotubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau), MAPT, MAPTL MTBT1 TAU
ApplicationELISA