BackgroundHistone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
DescriptionKDM8 Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ8N371
PurificationProtein G purified
ImmunogenRecombinant Human JmjC domain-containing protein 5 protein (151-380AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesLysine-specific demethylase 8 (EC:1.14.11.27), KDM8, JMJD5, JmjC domain-containing protein 5, Jumonji domain-containing protein 5
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000
Cart (0)
