BackgroundThis gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.
DescriptionIL17A Recombinant Monoclonal Antibody [11C11]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypehIgG4 (S228P)
Uniprot IDQ16552
PurificationAffinity Chromatography
ImmunogenRecombinant Human IL17A protein
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesCTLA 8 antibody; CTLA-8 antibody; CTLA8 antibody; cytotoxic T lymphocyte associated antigen 8 antibody; Cytotoxic T lymphocyte associated protein 8 antibody; Cytotoxic T lymphocyte associated serine esterase 8 antibody; Cytotoxic T-lymphocyte-associated antigen 8 antibody; IL 17 antibody; IL 17A antibody; IL-17 antibody; IL-17A antibody; IL17 antibody; IL17_HUMAN antibody; Il17a antibody; Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody; interleukin 17A antibody; Interleukin-17A antibody; interleukin17 antibody; Interleukin17A antibody; OTTHUMP00000016597 antibody; OTTMUSP00000046003 antibody
ApplicationELISA