BackgroundSpecifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
DescriptionGRK4 Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDP32298
Purification>95%, Protein G purified
ImmunogenRecombinant Human G protein-coupled receptor kinase 4 protein (1-245AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesG protein-coupled receptor kinase 4, G protein-coupled receptor kinase GRK4, GRK4, GPRK2L, GPRK4
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000