BackgroundG-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
DescriptionGCGR Recombinant Monoclonal Antibody [9G1]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypehIgG1
Uniprot IDP47871
PurificationAffinity Chromatography
ImmunogenRecombinant Human GCGR protein
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesGlucagon receptor (GL-R), GCGR
ApplicationELISA