BackgroundTyrosine-protein kinase that serves as a cell-surface receptor for fibroblast growth factors. Vital for controlling cell proliferation, differentiation, and apoptosis. Crucial in chondrocyte differentiation, bone development, and inner ear formation. Regulates osteogenesis and bone mineralization, promoting both chondrocyte apoptosis and cancer cell proliferation. Phosphorylates PLCG1, CBL, and FRS2, triggering signaling pathways involving diacylglycerol, inositol 1,4,5-trisphosphate, RAS, MAP kinases, and AKT1. Also influences vitamin D metabolism. Aberrant FGFR3 activity from mutations disrupts normal signaling. Overexpression or activation leads to PTPN11/SHP2, STAT1, STAT5A, and STAT5B activation. Isoform 3 interferes with FGF signaling by binding FGF1 and FGF2.
DescriptionFGFR3 Recombinant Monoclonal Antibody [5B6]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP22607
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human FGFR3
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesFibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333), FGFR3, JTK4
ApplicationELISA, IF; Recommended dilution: IF:1:20-1:200