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CPEB1 Polyclonal Antibody, Biotin Conjugated

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Application: ELISA
Areas of Research: RNA Processing & Modification
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
100% Guarantee: 6 months
Catalog No.SizePriceQty
A51236-05050 µg $256.00 
A51236-100100 µg $359.00 
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Product Overview

Background
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress.

Description
CPEB1 Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
Q9BZB8

Purification
>95%, Protein G purified

Immunogen
Recombinant Human Cytoplasmic polyadenylation element-binding protein 1 protein (1-486AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
CPE-BP1, CPE-binding protein 1, h-CPEB, hCPEB-1

Application
ELISA

User Guide & MSDS

[User Guide]*
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