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CHAC1 Polyclonal Antibody, HRP Conjugated

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Application: ELISA
Areas of Research: Apoptosis & Cell Death
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
100% Guarantee: 6 months
Catalog No.SizePriceQty
A58549-05050 µg $256.00 
A58549-100100 µg $359.00 
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Product Overview

Background
Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).

Description
CHAC1 Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
Q9BUX1

Purification
>95%, Protein G purified

Immunogen
Recombinant Human Glutathione-specific gamma-glutamylcyclotransferase 1 protein (43-264AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Glutathione-specific gamma-glutamylcyclotransferase 11 Publication, CHAC11, Blocks Notch protein1

Application
ELISA

User Guide & MSDS

[User Guide]*
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