BackgroundO-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs.
DescriptionBCDIN3D Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ7Z5W3
Purification>95%, Protein G purified
ImmunogenRecombinant Human Pre-miRNA 5'-monophosphate methyltransferase protein (1-292AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesPre-miRNA 5'-monophosphate methyltransferase, BCDIN3 domain-containing protein, BCDIN3D
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000