BackgroundExonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
DescriptionAEN Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Formulation0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ8WTP8
PurificationProtein G purified
ImmunogenRecombinant Human Apoptosis-enhancing nuclease protein (117-325AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesInterferon-stimulated 20 kDa exonuclease-like 1, SBBI58, ISG20L1, AEN
ApplicationELISA, IF; Recommended dilution: IF:1:200-1:1000
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