BackgroundComponent of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification.
DescriptionTPRKB Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ9Y3C4
Purification>95%, Protein G purified
ImmunogenRecombinant Human EKC/KEOPS complex subunit TPRKB protein (1-175AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesEKC/KEOPS complex subunit TPRKB, PRPK-binding protein, TP53RK-binding protein, TPRKB, CGI-121, My019
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200