BackgroundConverts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).
DescriptionPLAT Recombinant Monoclonal Antibody [32B1]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP00750
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from Human PLAT
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesTissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A, Tissue-type plasminogen activator chain B], PLAT
ApplicationELISA, FC; Recommended dilution: FC:1:50-1:200