BackgroundNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.
DescriptionNGF Recombinant Monoclonal Antibody [5F10]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Rat
IsotypeRabbit IgG
Uniprot IDP01138
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from human NGF
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesBeta-nerve growth factor (Beta-NGF), NGF, NGFB
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200