BackgroundPotent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
DescriptionBCL2L1 Recombinant Monoclonal Antibody [5E9]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse, Rat
IsotypeRabbit IgG
Uniprot IDQ07817
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Bcl-XL
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesBcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X), BCL2L1, BCL2L BCLX
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200