BackgroundMajor mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
DescriptionPYHIN1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman, Mouse
IsotypeIgG
Uniprot IDQ6K0P9
Purification>95%, Protein G purified
ImmunogenRecombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesPyrin and HIN domain-containing protein 1, Interferon-inducible protein X, PYHIN1, IFIX
ApplicationELISA, WB; Recommended dilution: WB:1:1000-1:5000