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   Home  »  Histone Methyltransferase (HMT) & Demethylase Assays 
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This is part of our Histone Modification Workflow,
click the image steps below for more details
.

HMT & Histone Demethylase Assays

Measure Histone Methyltransferase or Demethylase Activity/Inhibition

Histone methylation acts in both epigenetic gene activation and silencing. This dynamic and reversible process involves the transmission of methyl groups to histone proteins and is regulated by particular methyltransferase and demethylase enzymes. These enzymes are highly specific for substrate location and methylation degree. Quickly investigate histone methyltransferases (HMTs) or demethylases with our convenient ELISA-like assays that directly measure HMT or histone demethylase activity or inhibition levels from nuclear extracts of purified enzymes.


Schematic procedure for the EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K4) (Cat# P-3002).

About Histone Methyltransferase
Histone methyltransferases (HMTs) are a class of enzymes responsible for adding methyl groups to histone proteins. HMTs are primarily known to serve as gene silencers, methylating specific residues on histones. Alterations in the activation and expression of HMTs have been associated with various types of diseases, including many cancers, making them ideal candidates to study for potential drug therapies.

About Histone Demethylase
Histone demethylases are enzymes that can remove methyl groups from modified histones, justifying that histone methylation is not a permanent modification, as previously believed, but more of a dynamic process. Studies have shown that some demethylases are transcription regulators that can control gene expression by demethylating histones. Alterations and aberrant expression of histone demethylases appear to play a role in disease development, notably cancer. Studying the activity of these enzymes could help unravel the pathogenesis of various diseases and lead to possible treatment methods.

Histone Demethylase Activity/Inhibition Assay Kits

Kit Details

Click image to see more details
EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K4)
Measure activity of HMTs that specifically target histone H3 at lysine 4
  • Fast procedure that can be completed within 3 hours
  • No need for radioactivity, extraction, and chromatography
  • Specific measurement of activity/inhibition of H3-K4 histone methyltransferases
  • Flexible strip-well microplate format for manual or high throughput analysis

Catalog #: P-3002


Click image to see more details
EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K9)
Measure activity of HMTs that specifically target histone H3 at lysine 9
  • Fast procedure that can be completed within 3 hours
  • No need for radioactivity, extraction, and chromatography
  • Specific measurement of activity/inhibition of H3-K9 histone methyltransferases
  • Flexible strip-well microplate format for manual or high throughput analysis

Catalog #: P-3003


Click image to see more details
EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K27)
Measure activity of HMTs that specifically target histone H3 at lysine 27
  • Fast procedure that can be completed within 3 hours
  • No need for radioactivity, extraction, and chromatography
  • Specific measurement of activity/inhibition of H3-K27 histone methyltransferases
  • Flexible strip-well microplate format for manual or high throughput analysis

Catalog #: P-3005


Click image to see more details
Epigenase PRMT Methyltransferase (Type II-Specific) Activity/Inhibition Assay Kit
Measure activity of total type II PRMT using nuclear extracts or purified enzymes
  • Fast procedure that can be completed within 3 hours
  • Directly measures type II PRMT activity via a straightforward detection of PRMT-converted methylated products
  • Sensitive detection limit can be as low as 5 ng of purified PRMT5 enzyme
  • Flexible strip-well microplate format for manual or high throughput analysis

Catalog #: P-3088

Histone Methyltransferase (HMT) Assay Kits (*Fluorometric Version)

Kit Details

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Epigenase LSD1 Demethylase Activity/Inhibition Assay Kits
Measures LSD1 activity via a straightforward detection of LSD1-converted demethylated products
  • Rapid procedure that can be completed within 3 hours
  • Directly measures LSD1 activity via a straightforward detection of LSD1-converted demethylated products
  • Detects the effects of LSD1 inhibitors in vivo and in vitro
  • Sensitivity is significantly higher than H2O2/formaldehyde release-based assays
  • Flexible strip-well microplate format for manual or high throughput analysis

Catalog #s: P-3078 & P-3079*


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Epigenase JMJD2 Demethylase Activity/Inhibition Assay Kits
Measure JMJD2 activity via a straightforward detection of JMJD2-converted demethylated products
  • Rapid procedure that can be completed within 3 hours
  • Directly measures JMJD2 activity via a straightforward detection of JMJD2-converted demethylated product
  • Detects the effects of JMJD2 inhibitors in vivo and in vitro
  • Sensitivity is significantly higher than H2O2/formaldehyde release-based assays
  • Flexible strip-well microplate format for manual or high throughput analysis

Catalog #s: P-3080 & P-3081*


Click image to see more details
Epigenase JARID Demethylase Activity/Inhibition Assay Kits
Measure JARID activity via a straightforward detection of JARID-converted demethylated products
  • Rapid procedure that can be completed within 3 hours
  • Directly measures JARID activity via a straightforward detection of JARID-converted demethylated products
  • Detects the effects of JARID inhibitors in vivo and in vitro
  • Sensitivity is significantly higher than H2O2/formaldehyde release-based assays
  • Flexible strip-well microplate format for manual or high throughput analysis

Catalog #s: P-3082 & P-3083*


Click image to see more details
Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kits
Measure JMJD3 or UTX activity via a straightforward detection of JMJD3/UTX-converted demethylated products
  • Rapid procedure that can be completed within 3 hours
  • Directly measures JMJD3 or UTX activity via a straightforward detection of JMJD3/UTX-converted demethylated products
  • Detects the effects of JMJD3/UTX inhibitors in vivo and in vitro
  • Sensitivity is significantly higher than H2O2/formaldehyde release-based assays
  • Flexible strip-well microplate format for manual or high throughput analysis

Catalog #s: P-3084 & P-3085*



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